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Based on the STEP 1 clinical study, the semaglutide-treated group reported weight loss beginning with the first assessment after randomization at week 4, reaching its lowest reported weight loss at week 60.[2,4] STEP 1 included 1961 patients randomly assigned to treatment with semaglutide or placebo combined with diet and exercise.[4] Dosage Forms And Strengths Semaglutide is currently available as a clear and colorless injectable solution.[2] The injections come in five different pre-filled, disposable, and single-dose pens[2]: 0.25 mg/0.5 mL 0.5 mg/0.5 mL 1 mg/0.5 mL 1.7 mg/0.5 mL 2.4 mg/0.5 mL Safety Common side effects of semaglutide are gastrointestinal-related.[2,5] These are nausea, vomiting, and diarrhea